On January 3, 2019, the first lunar farside in-situ exploration mission, China’s Chang’e 4 (CE-4), success fully landed in Von Karman crater within the South Pole-Aitken (SPA) basin. The CE-4 mission provided a host platform and opened its science payload resources to the international community. Science payloads from Germany, Sweden, the Netherlands and Kingdom of Saudi Arabia were aboard CE-4. It has explored effective models of international cooperation, accumulated cooperation experience, and provided a reference for the implementation of broader and deeper cooperation in major projects. This paper summarizes the practical experience of international cooperation on CE-4, analyzes the difficulties and existing problems of science payloads management, explains the current manage ment methods, and puts forward suggestions for the development of broader international cooperation for the future.