Abstract: Today, the “division” thought of “Reductionism” makes people feel helpless and gradually recognize the consequence of the social alienation. Based on 20 years’ experience in America, 28 years’ practice in China’s space industry, and nearly 30 years’ research in his later years, QIAN Xuesen integrated the Western Reductionism with the Eastern Holism to form the QIAN Xuesen think tank thought and the Hall for Workshop of Metasynthetic Engineering from qualitative to quantitative, promoting space internationalization to play an irreplaceable role in the development of technology, engineering and industrialization.