Abstract: The most distinctive feature of the new era is integration and innovation. With the rapid development of information technology and big data technology, the data era brought by artificial intelligence is coming. The systems engineering theory and methods summarized from engineering practice show more and more its importance and indispensability. The overall design department thoughts founded by scientist QIAN Xuesen is the result of the practice of systematic engineering science theory. The new development of the overall design department will inject intellectual support and technical support into the modernization of the national governance system and capabilities.